ETHYL 2-CHLORO-5-IODOBENZOATE synthesis

Yield:289039-54-9 1.74 g

Reaction Conditions:

with hydrogenchloride in water; for 12 h;Reflux;

Steps:

17.17-1 17-1. Synthesis of Compound (43)

5-iodoaniline-2-chlorobnenzoic acid 3. 3g soln. ethanol 150 ml, concentrated hydrochloric acid 0. 11g is added, heated under reflux for 12 hours. After returning the reaction solution to room temperature, is diluted with water, adding an aqueous solution of sodium hydroxide 1N, 3 times extracted with ethyl acetate. The organic layer, washed with saturated saline solution, dried with magnesium sulfate waterlessly org. layer. By concentrating the pressure somas, 5-iodoaniline-2-ethyl chlorobnenzoic (43) 1. 74g is obtained.

References:

JP5743418,2015,B2 Location in patent:Paragraph 0176; 0177; 0178