Ethyl-2-cyano-3-(3-cyanophenyl)prop-2-enoate synthesis

Yield:18153-16-7 98%

Reaction Conditions:

with titanium(IV) tetraethanolate in neat (no solvent) at 110; for 0.0833333 h;Microwave irradiation;Sealed tube;Knoevenagel Condensation;Time;Temperature;

Steps:

3.3. General Experimental Procedure for the Synthesis ofα,β-unsaturated Compounds under Microwave Irradiation3a-3u

General procedure: A dry CEM microwave glass vial (10 mL) equipped witha magnetic stir bar was charged with aldehyde (1.1 eq), diethylmalonate/ethyl cyanoacetate (1.0 eq) and titanium ethoxide(1.1 eq). The sealed vial was subjected to microwaveirradiation at 110 °C using power 150 W for 5 minutes. Aftercooling to room temperature (rt) the reaction mixture wasdirectly charged onto a silica gel column (eluent: petroleumether/ ethyl acetate = 80:20) to provide the correspondingα,β-unsaturated compounds.

References:

Ramaiah, Manjunatha M.;Shivananju, Nanjunda Swamy;Shubha, Priya Babu [Letters in Organic Chemistry,2020,vol. 17,# 2,p. 107 - 115]