ETHYL 2-(METHYLSULFONYL)PROPANOATE synthesis
- Product Name:ETHYL 2-(METHYLSULFONYL)PROPANOATE
- CAS Number:73017-82-0
- Molecular formula:C6H12O4S
- Molecular Weight:180.22
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73017-82-0
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Yield:73017-82-0 84.89%
Reaction Conditions:
in ethanol at 77; for 20 h;Inert atmosphere;Large scale;
Steps:
1.a
A solution of ethyl 2-chloropropanoate (1000 g, 7.35 mol) and sodium methanesulfinate (899 g, 8.82 mol) in ethanol (1350 mL) was stirred at 77 °C for 20 hrs. The reaction mixture was allowed to cool to r.t. The solids were removed by filtration through celite, and the filter pad was washed with ethanol. The filtrates were combined and concentrated in vacuo. The crude product was suspended in EtOAc and H20. The organic phase was washed by brine, dried over Na2S04, filtered, concentrated to give ethyl 2-(methylsulfonyl)propanoate (1124 g, 84.9%) as a yellow oil. 1HNMR: 400 MHz CDCI3δ: 4.25-4.28 (m, 2H), 3.84-3.90 (m, 1 H), 3.04 (s, 3H), 1 .63-1 .65 (m, 3H), 1 .29-1 .33 (m, 3H). Part B
References:
WO2017/98440,2017,A1 Location in patent:Page/Page column 109
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73017-82-0
50 suppliers
$92.00/250mg