ChemicalBook CAS DataBase List ETHYL 2-OXO-1-CYCLOOCTANECARBOXYLATE 9&

ETHYL 2-OXO-1-CYCLOOCTANECARBOXYLATE 9& synthesis

9synthesis methods

Product Name:ETHYL 2-OXO-1-CYCLOOCTANECARBOXYLATE 9&
CAS Number:774-05-0
Molecular formula:C10H16O3
Molecular Weight:184.23

95-92-1 Synthesis

95-92-1
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$5.00/5 g

502-42-1
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$10.00/1g

774-05-0
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$87.00/200MG

Yield: 50%

Reaction Conditions:

with sodium ethanolate in ethanol at -5 - 25; for 5 h;

Steps:

1 The preparation of compound (2)
Compound (1) (8.30g, 0.074mol), diethyl oxalate (10.80g, 0.074mol) and sodium ethoxide (2.52g, 0.037mol) were dissolved in 40mL of absolute ethanol and reacted at -5°C to 10°C. The mixture was stirred at room temperature (25°C) for 5 h. After 5h, the mixture was acidified and filtered to remove the filter cake. The filtrate was extracted with dichloromethane, dried, concentrated in vacuo, and purified by column chromatography to obtain an orange-red viscous liquid compound (2) (6.81 g; 50%).

References:

China Agricultural University;Yang Xinling;Jiang Biaobiao;Jin Xiaoyu;Zhang Li;Guo Bingbo CN111574452, 2020, A Location in patent:Paragraph 0042-0044