![](/CAS/20180703/GIF/71721-67-0.gif)
ETHYL 2-PYRIDYLGLYOXYLATE OXIME synthesis
- Product Name:ETHYL 2-PYRIDYLGLYOXYLATE OXIME
- CAS Number:71721-67-0
- Molecular formula:C9H10N2O3
- Molecular Weight:194.19
![Ethyl 2-pyridylacetate](/CAS/GIF/2739-98-2.gif)
2739-98-2
205 suppliers
$11.00/1g
![ETHYL 2-PYRIDYLGLYOXYLATE OXIME](/CAS/20180703/GIF/71721-67-0.gif)
71721-67-0
32 suppliers
$28.60/50mg
Yield:71721-67-0 91%
Reaction Conditions:
with acetic acid;sodium nitrite in water at 0 - 20; for 24.25 h;
Steps:
Ethyl 2-hydroxyimino-2-(pyridin-2-yl) acetate (7)
To a stirred solution of ethyl 2-pyridylacetate 6 (50.0 g,302.6 mmol s) in water (120 mL) cooled at 0 C, glacial acetic acid(120 mL) was added. After stirring the reaction mixture for 15 min,an aqueous solution of sodium nitrite (40.5 g, 605.3 mmol s in60 mL of water) was added over a period of 15 min. The reactionmixture was then stirred at r.t. for 24 h before it was diluted withwater (200 mL). The solids thus precipitated were filtered, washedwith water and dried under reduced pressure at 50 C to obtain theabove titled compound 7 (53.8 g) as light brown gummy liquid in 91% yield
References:
Nirogi, Ramakrishna;Mohammed, Abdul Rasheed;Shinde, Anil K.;Bogaraju, Narsimha;Gagginapalli, Shankar Reddy;Ravella, Srinivasa Rao;Kota, Laxman;Bhyrapuneni, Gopinadh;Muddana, Nageswara Rao;Benade, Vijay;Palacharla, Raghava Chowdary;Jayarajan, Pradeep;Subramanian, Ramkumar;Goyal, Vinod Kumar [European Journal of Medicinal Chemistry,2015,vol. 103,p. 289 - 301]