ETHYL 3-AMINOCINNAMATE synthesis
- Product Name:ETHYL 3-AMINOCINNAMATE
- CAS Number:6328-01-4
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
Yield:6328-01-4 99%
Reaction Conditions:
with palladium 10% on activated carbon;triethylamine in 1,4-dioxane at 100; for 20 h;Schlenk technique;Heck Reaction;
Steps:
Synthesis of Alkenylanilines; Typical Procedure
General procedure: A mixture of 2-iodoaniline 1 (0.50 mmol) and Pd/C (10 wt% palladium on activated carbon paste and 50% moisture, 10 wt% wet Pd/C based on starting material 1) in 1,4-dioxane (3 mL) was added into a Schlenk flask (25 mL) and stirred at r.t. Ethyl acrylate (100 mg, 1.0 mmol, 2.0 equiv) and Et3N (101 mg, 1.0 mmol, 2.0 equiv) were added and the mixture was stirred at 100 °C until the reaction was complete. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography.
References:
Zhou, Xiao-Yu;Chen, Xia;Wang, Liang-Guang [Synthesis,2017,vol. 49,# 24,p. 5364 - 5370] Location in patent:supporting information
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