Ethyl 3-aminothieno[2,3-c]pyridine-2-carboxylate synthesis
- Product Name:Ethyl 3-aminothieno[2,3-c]pyridine-2-carboxylate
- CAS Number:78790-83-7
- Molecular formula:C10H10N2O2S
- Molecular Weight:222.26
13958-98-0
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623-51-8
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78790-83-7
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Yield:78790-83-7 67%
Reaction Conditions:
with sodium ethanolate in N,N-dimethyl-formamide; for 2 h;
Steps:
1.C
Step C: Preparation of ethyl 3-aminothieno[2,3-c]pyridine-2-carboxylate: 3-Bromoisonicotinonitrile (2000 mg, 10.93 mmol) was combined with ethyl 2-mercaptoacetate (1.205 mL, 10.93 mmol) in 50 mL DMF. Sodium ethanolate (4.080 mL, 10.93 mmol) was added, and the reaction mixture was stirred for 2 hours. The reaction mixture was transferred to separatory funnel, diluted with H2O, brine, NaHCO3 and extracted with EtOAc. The combined organic layers were combined, dried over Na2SO4, and concentrated to a yellow solid. LCMS confirmed desired product. The crude product was pre-adsorbed onto silica column and eluted with 1-5% MeOH/CH2Cl2 to provide 1.631 g (67%) of the desired product. MS(+) m/z=223.1.
References:
US2007/49603,2007,A1 Location in patent:Page/Page column 38; 27
68325-15-5
246 suppliers
$6.00/100mg
623-51-8
241 suppliers
$7.00/25g
78790-83-7
40 suppliers
$45.00/25mg
20577-26-8
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$24.00/1g
623-51-8
241 suppliers
$7.00/25g
78790-83-7
40 suppliers
$45.00/25mg