Ethyl 3-bromo-5-nitrobenzoate synthesis
- Product Name:Ethyl 3-bromo-5-nitrobenzoate
- CAS Number:690260-94-7
- Molecular formula:C9H8BrNO4
- Molecular Weight:274.07
64-17-5
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690260-94-7
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Yield:690260-94-7 99%
Reaction Conditions:
with thionyl chloride at 0 - 80;
Steps:
1 Step 1: Ethyl 3-bromo-5-nitrobenzoate
Into a 500-mL round-bottom flask, was placed 3-bromo-5-nitrobenzoic acid (25 g, 101.6 mmol), EtOH (200 mL). This was followed by the addition of SOCl2 (15 mL) dropwise with stirring at 0oC. The resulting solution was stirred for 4 h at 80oC and then was quenched by the addition of 50 mL water. The resulting solution was extracted with 3x50 mL of DCM and the organic layers combined and concentrated under vacuum. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1:20 to 1:10). This resulted in 27.5 g (99%) of the title compound as a white solid.
References:
WO2017/184623,2017,A1 Location in patent:Page/Page column 127
64-17-5
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$10.00/50g
51339-40-3
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690260-94-7
64 suppliers
$17.00/250mg
6307-83-1
213 suppliers
$5.00/250mg
690260-94-7
64 suppliers
$17.00/250mg
121-92-6
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690260-94-7
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