ethyl 3-[(cyclopropylmethyl)amino]propanoate synthesis
- Product Name:ethyl 3-[(cyclopropylmethyl)amino]propanoate
- CAS Number:182559-61-1
- Molecular formula:C9H17NO2
- Molecular Weight:171.24
2516-47-4
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Yield:182559-61-1 100%
Reaction Conditions:
in ethanol at 20; for 16 h;Cooling with ice;
Steps:
47.1 Step 1: Synthesis of ethyl 3-((cyclopropylmethyl)amino)propionate
The material cyclopropanemethanamine (10 g, 99.88 mmol, 1.0 eq.) was dissolved in ethanol (30 mL).
The solution was added with ethyl acrylate (12.67 g, 89.89 mmol, 0.9 eq.) dropwise in a slow manner under an ice bath, and after addition, reaction was carried out at room temperature for 16 h.
After no materials were left, as detected by TLC, the reaction solution was concentrated under reduced pressure to give the product (15.39 g, yield: 100%).
References:
EP3892621,2021,A1 Location in patent:Paragraph 0697-0699