ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate synthesis
- Product Name:ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate
- CAS Number:7403-65-8
- Molecular formula:C10H20O3
- Molecular Weight:188.26
Yield:7403-65-8 82%
Reaction Conditions:
Stage #1: ethyl 2-bromoisobutyrate;isobutyraldehydewith bis(cyclopentadienyl)titanium dichloride;2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2,5-cyclo-hexadiene in tetrahydrofuran at 20; for 14 h;Inert atmosphere;Reformatsky Reaction;
Stage #2: with hydrogenchloride in tetrahydrofuran;diethyl ether;Inert atmosphere;
References:
Saito, Teruhiko;Nishiyama, Haruka;Tanahashi, Hiromasa;Kawakita, Kento;Tsurugi, Hayato;Mashima, Kazushi [Journal of the American Chemical Society,2014,vol. 136,# 13,p. 5161 - 5170] Location in patent:supporting information
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