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ChemicalBook CAS DataBase List Ethyl (3E)-3-(2-phenylhydrazin-1-ylidene)butanoate
6078-46-2

Ethyl (3E)-3-(2-phenylhydrazin-1-ylidene)butanoate synthesis

2synthesis methods
-

Yield:6078-46-2 90.4%

Reaction Conditions:

in ethanol at -5 - 0; for 1 h;Solvent;

Steps:

3.1

(1) 108g of phenylhydrazine addedInto 864mL ethanol,Add 136.5g ethyl acetoacetate under temperature control -50,React at -5°C for 1 hour,After the reaction, take out half of the reaction solution and addThe mass fraction is 100 mL of 20% sodium bicarbonate solution to quench the reaction,Add dichloromethane to extract,Concentrate under reduced pressure at 35°C to obtain an oily substance,Column chromatography purification, drying,Obtained 99.76g of transition state impurities,The yield was 90.4%.

References:

CN113072502,2021,A Location in patent:Paragraph 0023; 0038; 0042; 0046; 0047; 0054

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