ChemicalBook CAS DataBase List ETHYL 3FLUOROCINNAMATE

ETHYL 3FLUOROCINNAMATE synthesis

9synthesis methods

Product Name:ETHYL 3FLUOROCINNAMATE
CAS Number:351-46-2
Molecular formula:C11H11FO2
Molecular Weight:194.2

Ethyl (triphenylphosphoranylidene)acetate

1099-45-2
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$6.00/5g

456-48-4 Synthesis

456-48-4
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$9.00/25g

351-46-2
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$116.64/1gm:

Yield: 99%

Reaction Conditions:

in dichloromethane at 20; for 16 h;

Steps:

General procedure for the preparation of 4
General procedure: Compounds 4 was prepared following a previously reported methodology.^[3] Compounds 2 (8 g, 22.8 mmol) was added to a stirring mixture of the corresponding benzaldehyde (21.8 mmol) in dichloromethane (25 ml) and the resulting solution was stirred at room temperature for 16 h. The solvent was evaporated and the resulting residue dissolved in 50 mL hexane/Et₂O (9:1). The mixture was then stirred for another 15 min and filtered. The filtrate was evaporated and the residue subjected to flash chromatography with hexane/Et₂O (7:3) to afford the corresponding compound 4.

References:

Obi, Grace;Van Heerden, Fanie R. [Synthetic Communications,2018,vol. 48,# 12,p. 1482 - 1486] Location in patent:supporting information

64-17-5 Synthesis