ChemicalBook CAS DataBase List ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE

ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE synthesis

9synthesis methods

Product Name:ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE
CAS Number:21190-16-9
Molecular formula:C6H9N3O2
Molecular Weight:155.15

64-17-5 Synthesis

64-17-5
707 suppliers
$10.00/50g

360-97-4 Synthesis

360-97-4
368 suppliers
$5.00/250mg

21190-16-9
89 suppliers
$75.00/100mg

Yield: 54%

Reaction Conditions:

with sulfuric acid at 120; for 24 h;Sealed tube;

Steps:

49.1 Synthesis of ethyl 5-amino-1H-imidazole-4-carboxylate:
A mixture of 5-amino-1H-imidazole-4-carboxamide (30.0 g, 238 mmol) and sulfuric acid (70.0 g, 714 mmol) in ethanol (300 mL) was heated to 120 °C in a sealed tube for 24 h. The reaction mixture was cooled to room temp, and the solvent was removed in vacuo. The residue was purified via silica gel column chromatography to give ethyl 5-amino-1H-imidazole-4-carboxylate (20.0 g, 54%). MS (ESI) calcd for C₆H₉N₃O₂: 155.07

References:

SIRTRIS PHARMACEUTICALS, INC.;CASAUBON, Rebecca, L.;NARAYAN, Radha;OALMANN, Christopher;VU, Chi, B. WO2013/59587, 2013, A1 Location in patent:Page/Page column 152

360-97-4 Synthesis

360-97-4
368 suppliers
$5.00/250mg

21190-16-9
89 suppliers
$75.00/100mg

References

64-17-5 Synthesis

64-17-5
707 suppliers
$10.00/50g

72-40-2 Synthesis