Ethyl 4-broMo-1-benzothiophene-2-carboxylate synthesis

5synthesis methods

Product Name:Ethyl 4-broMo-1-benzothiophene-2-carboxylate
CAS Number:93103-82-3
Molecular formula:C11H9BrO2S
Molecular Weight:285.16

360575-28-6 Synthesis

360575-28-6
275 suppliers
$10.00/1g

623-51-8
233 suppliers
$7.00/25g

Ethyl 4-broMo-1-benzothiophene-2-carboxylate

93103-82-3
33 suppliers
$75.00/1g

Yield:93103-82-3 66%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60;Inert atmosphere;Further stages;

Steps:

14.2 Step 2:

Step 2: (0365) A three-necked flask was charged with N, N-dimethylformamide (250 ml) and potassium carbonate (51.5 g, 373 mmol). Ethyl thioglycolate (13.7 ml) was added dropwise at room temperature under a nitrogen atmosphere followed by rapid addition of compound 14-b (25.2 g, 124 mmol). The mixture was stirred at 60° C. overnight, diluted with ethyl acetate (300 ml), filtered, and the filtrate was washed with water and saturated brine, dried, concentrated and subjected to column chromatography to obtain compound 14-c (23 g, yield: 66%).

References:

US2017/158680,2017,A1 Location in patent:Paragraph 0361; 0364; 0365

5194-37-6 Synthesis