![](/CAS/20130318/GIF/CB02599126.gif)
ETHYL 4-BROMO-2-CHLOROBENZOATE synthesis
- Product Name:ETHYL 4-BROMO-2-CHLOROBENZOATE
- CAS Number:76008-74-7
- Molecular formula:C9H8BrClO2
- Molecular Weight:263.52
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
704 suppliers
$10.00/50g
![4-Bromo-2-chlorobenzoic acid](/CAS/GIF/59748-90-2.gif)
59748-90-2
275 suppliers
$8.00/1g
![ETHYL 4-BROMO-2-CHLOROBENZOATE](/CAS/20130318/GIF/CB02599126.gif)
76008-74-7
25 suppliers
$120.18/250mgs:
Yield:76008-74-7 95%
Reaction Conditions:
with sulfuric acid at 0;Reflux;
Steps:
ethyl 4-bromo-2-chlorobenzoate (2)
To a mixture of 4-bromo-2-chlorobenzoic acid 1 (1.9 g, 8.1 mmol) in EtOH (50 mL) was added H2SO4 (5 mL) dropwise carefully at 0 °C. The resulting mixture was refluxed overnight. The volatile phase removed under reduced pressure. The residue was diluted with EA (100 mL), which was washed with water (2 x 50 mL) and brine, dried over sodium sulfate, filtered and concentrated. This resulted in the title compound (2.0 g, 95%) as brown oil. MS (ESI): m/z = 263.0/265.0 [M + H]+.
References:
WO2015/48662,2015,A2 Location in patent:Page/Page column 118-119
![Ethyl 4-bromobenzoate](/CAS/GIF/5798-75-4.gif)
5798-75-4
190 suppliers
$6.00/5g
![ETHYL 4-BROMO-2-CHLOROBENZOATE](/CAS/20130318/GIF/CB02599126.gif)
76008-74-7
25 suppliers
$120.18/250mgs: