ETHYL 5-(2-CHLOROPHENYL)-5-OXOVALERATE synthesis
1synthesis methods
- Product Name:ETHYL 5-(2-CHLOROPHENYL)-5-OXOVALERATE
- CAS Number:898759-03-0
- Molecular formula:C13H15ClO3
- Molecular Weight:254.71
Yield:898759-03-0 65%
Reaction Conditions:
Stage #1: Ethyl 4-bromobutyratewith magnesium;lithium chloride;zinc(II) chloride in tetrahydrofuran at 20; for 1.5 h;Inert atmosphere;
Stage #2: with copper(I) cyanide di(lithium chloride) in tetrahydrofuran at -30;Inert atmosphere;
Stage #3: o-chlorobenzoyl chloride in tetrahydrofuran at -30;Inert atmosphere;
References:
Bluemke, Tobias D.;Piller, Fabian M.;Knochel, Paul [Chemical Communications,2010,vol. 46,# 23,p. 4082 - 4084] Location in patent:supporting information; experimental part