Ethyl 5-broMo-6-Methoxypicolinate synthesis
- Product Name:Ethyl 5-broMo-6-Methoxypicolinate
- CAS Number:1214337-82-2
- Molecular formula:C9H10BrNO3
- Molecular Weight:260.08
64-17-5
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Yield:1214337-82-2 99%
Reaction Conditions:
toluene-4-sulfonic acid for 48 h;Reflux;
Steps:
3.3
Step 3. Synthesis of ethyl 5-bromo-6-methoxypyridine-2-carboxylate (C16). para-Toluenesulfonic acid hydrate (roughly 0.3 g) was added to a solution of 5- bromo-6-methoxypyridine-2-carboxylic acid (C15) (12.2 g, 52.6 mmol) in ethanol (300 mL). The reaction mixture was heated at reflux for 48 hours, then concentrated in vacuo to provide the title product. Yield: 13.5 g, 51 .9 mmol, 99%.
References:
WO2011/48525,2011,A1 Location in patent:Page/Page column 57
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