Ethyl 5-chloro-2-ethoxybenzoate synthesis
- Product Name:Ethyl 5-chloro-2-ethoxybenzoate
- CAS Number:73119-79-6
- Molecular formula:C11H13ClO3
- Molecular Weight:228.67
Yield:73119-79-6 88.3%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 15 h;
Steps:
Step 3) ethyl 5-chloro-2-ethoxybenzoate
5-chloro-salicylic acid 50.0g the (290mmol) N, N- dimethylformamideWas dissolved in 250mL, potassium carbonate 120g (869mmol) and iodide ethane 69.9mL (136g, 869mmol) was added, and the mixture was stirred for 15 hours at room temperature. The reaction mixture added water, added ethyl acetate extract was, the organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. Filtered, The filtrate was concentrated, the resulting crude product was purified by silica gel column chromatography (Biotage, eluent; hexane / ethyl acetate = 95 / 5-70 / 30) was purified using the title compound 58. to give 6g of (88.3% yield) as a solid.
References:
JP2016/56134,2016,A Location in patent:Paragraph 0150; 0151; 0154
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