![](/CAS/GIF/24985-85-1.gif)
Ethyl 5-hydroxyindole-2-carboxylate synthesis
- Product Name:Ethyl 5-hydroxyindole-2-carboxylate
- CAS Number:24985-85-1
- Molecular formula:C11H11NO3
- Molecular Weight:205.21
![ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE](/CAS/GIF/37033-95-7.gif)
37033-95-7
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$35.09/Price $/250mgs:
![Ethyl 5-hydroxyindole-2-carboxylate](/CAS/GIF/24985-85-1.gif)
24985-85-1
129 suppliers
$19.00/100mg
Yield:24985-85-1 99%
Reaction Conditions:
with hydrogen;10% palladium on activated carbon in ethanol; for 20 h;
Steps:
1.c Scheme 1; EXAMPLE 1; Preparation of 5-(2-Chloro-5-hydroxybenzyloxy)-1-[(2-thiophen-3-yl)ethyl]-1H-indole-2-carboxylic Acid; c) 5-Hydroxyindole-2-carboxylic Acid Ethyl Ester
A solution of 5-benzyloxyindole-2-carboxylic acid ethyl ester (10 g, 34 mmol) in ethanol (250 mL) was treated with 10% Pd/C and hydrogenated under atmospheric pressure (double-walled balloon) for 20 h. The reaction mixture was diluted with EtOAc and filtered through Celite. Evaporation of the filtrate in vacuo gave the title compound as a tan solid (7 g, 99%). 1H NMR (400 MHz, CDCl3) δ 8.86 (br s, 1H), 7.29 (d, J=8.80 Hz, 1H), 7.11 (s, 1H), 7.06 (s, 1H), 6.94 (d, J=8.70 Hz, 1H), 4.83 (br s, 1H), 4.42 (q, J=7.09 Hz, 2H), 1.41 (t, J=7.08 Hz, 3H).
References:
US6670388,2003,B1 Location in patent:Page column 6
![ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE](/CAS/GIF/4792-58-9.gif)
4792-58-9
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![Ethyl 5-hydroxyindole-2-carboxylate](/CAS/GIF/24985-85-1.gif)
24985-85-1
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$19.00/100mg
![5-Hydroxyindole-2-carboxylic acid](/CAS/GIF/21598-06-1.gif)
21598-06-1
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![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
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![Ethyl 5-hydroxyindole-2-carboxylate](/CAS/GIF/24985-85-1.gif)
24985-85-1
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$19.00/100mg
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617-35-6
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$5.00/10g
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123-30-8
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$10.00/5g
![Ethyl 5-hydroxyindole-2-carboxylate](/CAS/GIF/24985-85-1.gif)
24985-85-1
129 suppliers
$19.00/100mg
![5-Hydroxyindole-2-carboxylic acid](/CAS/GIF/21598-06-1.gif)
21598-06-1
139 suppliers
$29.00/250mg
![Ethyl 5-hydroxyindole-2-carboxylate](/CAS/GIF/24985-85-1.gif)
24985-85-1
129 suppliers
$19.00/100mg