ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE synthesis
1synthesis methods
- Product Name:ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE
- CAS Number:897399-74-5
- Molecular formula:C12H16N2O2
- Molecular Weight:220.27
Yield:897399-74-5 80%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60;
Steps:
17.1
Step 1 Synthesis of 6-Pyrrolidin-1-yl-nicotinic acid ethyl ester Potassium carbonate (3.89 g, 28 mmol) was added to a stirred solution of pyrrolidine (1.0 g, 14 mmol) and 6-chloronicotinic acid ethyl ester (2.87 g, 15.5 mmol) in DMF (10 mL) and the resulting mixture was stirred with heating at 60° C. overnight. Cold water was then added to and the resulting precipitate was dried to afford 498 mg (80%) of 6-pyrrolidin-1-yl-nicotinic acid ethyl ester. LCMS-purity: 97%.
References:
US2010/160323,2010,A1 Location in patent:Page/Page column 22