ETHYL 7-(4-METHYLPHENYL)-7-OXOHEPTANOATE synthesis
- Product Name:ETHYL 7-(4-METHYLPHENYL)-7-OXOHEPTANOATE
- CAS Number:122115-49-5
- Molecular formula:C16H22O3
- Molecular Weight:262.34
25542-62-5
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$6.00/5g
874-60-2
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122115-49-5
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$303.00/1g
Yield:122115-49-5 70%
Reaction Conditions:
Stage #1: 6-bromo-hexanoic acid ethyl esterwith magnesium;lithium chloride;zinc(II) chloride in tetrahydrofuran at 20; for 2.5 h;Inert atmosphere;
Stage #2: with copper(I) cyanide di(lithium chloride) in tetrahydrofuran at -30;Inert atmosphere;
Stage #3: 4-methyl-benzoyl chloride in tetrahydrofuran at -30;Inert atmosphere;
References:
Bluemke, Tobias D.;Piller, Fabian M.;Knochel, Paul [Chemical Communications,2010,vol. 46,# 23,p. 4082 - 4084] Location in patent:supporting information; experimental part