Ethyl fluoroacetate synthesis
- Product Name:Ethyl fluoroacetate
- CAS Number:459-72-3
- Molecular formula:C4H7FO2
- Molecular Weight:106.1
105-39-5
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459-72-3
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Yield:459-72-3 83.5%
Reaction Conditions:
with potassium fluoride;N-hexadecyl-N,N,N-trimethylammonium bromide in sulfolane at 120 - 165; for 2 h;Temperature;Reagent/catalyst;Solvent;
Steps:
1-9; 1-5 Example 5
Add 5g acetamide and 10mL sulfolane to a 100mL flask, heat at 165°C to remove water for 30min, cool down to 120°C, add 12.255g (0.1mol) of ethyl chloroacetate, and 7.26g (0.125mol) of potassium fluoride, Cetyltrimethylammonium bromide 1.73 (0.005mol) was reacted for 2h, after the reaction was over, the filtrate was filtered while hot, and the obtained filtrate was distilled at 120°C for 3h to obtain ethyl fluoroacetate. The obtained product was analyzed by GC-MS and the yield was 83.5%.
References:
CN114940647,2022,A Location in patent:Paragraph 0044-0071
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