ethyl N,N-bis(2-chloroethyl)carbamate synthesis
- Product Name:ethyl N,N-bis(2-chloroethyl)carbamate
- CAS Number:5467-15-2
- Molecular formula:C7H13Cl2NO2
- Molecular Weight:214.09
Yield:5467-15-2 100%
Reaction Conditions:
with potassium carbonate in acetone; for 4 h;Heating / reflux;
Steps:
26
bis(2-Chloroethyl)amine hydrochloride (Tokyo Chemical Industry CO., LTD., 3.0 g) was dissolved in acetone (50 ml), potassium carbonate (3.0 g) and ethyl chloroformate (2.4 ml) were added, and the mixture was heated under reflux for 4 hr. After completion of the reaction, the mixture was cooled to room temperature, and the solid was filtered off. The filtrate was evaporated under reduced pressure to give ethyl bis(2-chloroethyl)carbamate (3.7 g, yield 100%). 1H-NMR(300MHz,CDCl3)δ(ppm) : 1.28(3H,t,J=7.1Hz), 3.63-3.67(8H,m), 4.17(2H,q,J=7.1Hz).
References:
EP1714961,2006,A1 Location in patent:Page/Page column 18
