ethyl naphtho[2,3-b]thiophene-2-carboxylate synthesis
- Product Name:ethyl naphtho[2,3-b]thiophene-2-carboxylate
- CAS Number:51925-17-8
- Molecular formula:C15H12O2S
- Molecular Weight:256.32
19397-74-1
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Yield:51925-17-8 87.2%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane;Reflux;γ-Irradiation;
Steps:
15a 15a) Naphthalene [1,2-b]thiophene-2-carboxylic acid ethyl ester
The compound 4,5-dihydronaphthalene [1,2-b]thiophene-2-carboxylic acid ethyl ester (0.5 g, 1.94 mmol) and benzoyl peroxide (5 mg) obtained by the method of 14b) were dissolved in dry. In a solution of CC14 (8 mL), NBS (0.52 g, 2.9 mmol) was. The reaction solution was refluxed while being irradiated with a 200 W fluorescent lamp, and the generated hydrogen bromide gas was purged with a nitrogen stream, and the reaction was further refluxed for 1 hour. The reaction was completed to completion by TLC, and the reaction mixture was cooled, filtered and concentrated to give a crude product.With ethyl acetate /Recrystallization from n-hexane gave a yellow solid, 0.43 g.The yield was 87.2%.
References:
CN108727416,2018,A Location in patent:Paragraph 0349; 0350; 0351
3262-03-1
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529-34-0
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