EXP561 synthesis

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: N-benzyl-trimethylammonium hydroxide / methanol; tert-butyl alcohol / 1 h / Cooling with ice
2.1: potassium hydroxide / water / Reflux
3.1: acetic acid; potassium acetate; acetic anhydride / 2 h / Reflux
4.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux
5.1: hydrazine hydrate / 2.5 h / 120 °C
5.2: 2 h / 160 - 220 °C
6.1: acetic acid; hydrogen; palladium on activated charcoal / ethanol / 2844.39 Torr

References:

WO2017/160632,2017,A1