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Febuxostat impurity 37 synthesis

1synthesis methods
3-Cyano-4-propoxybenzoic acid

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Febuxostat impurity 37

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: thionyl chloride / dichloromethane / 2 h / Reflux
2: ammonia / methanol; dichloromethane / 0.5 h / Cooling with ice
3: trichlorophosphate / 1 h / Reflux

References:

EP2383262,2011,A1

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