Fluocortolone synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in methanol;ethanol at 0 - 5; for 1.5 h;Inert atmosphere;

Steps:

3 Preparation of Compounds of Formula II
4.01g of the compound of formula IV into 100ml of methanol and 30ml three reaction flask, nitrogen, and dissolved with stirring, maintaining the temperature at 0-5 deg.] C, was added 1ml 2% NaOH / ethanol solution, 1.5 h, acetic acid was used to adjust the PH value 6.5 -7.5, concentrated under reduced pressure, cooled to below 5 after concentration, left to stand for 1 hour, filtered, and dried at 0-5 deg.] C, and recrystallized to give 3.2g of product of formula II fluocortolone.

References:

Tianjin Taipingyang Pharmaceutical Co., Ltd.;Song Decheng CN107793460, 2018, A Location in patent:Paragraph 0031; 0032

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