FLUORESCEIN CHLORIDE synthesis
- Product Name:FLUORESCEIN CHLORIDE
- CAS Number:630-88-6
- Molecular formula:C20H10Cl2O3
- Molecular Weight:369.2
2321-07-5
351 suppliers
$6.00/25g
630-88-6
90 suppliers
$51.00/1g
Yield:630-88-6 90.5%
Reaction Conditions:
with sulfolane;thionyl chloride in N,N-dimethyl-formamide at 60 - 80; for 2.5 h;Temperature;
Steps:
1 1, the synthesis of intermediate A, the reaction is as follows:
In the presence of a stirrer,thermometer,Reflux condenser and acid gas absorption device in the three bottles,50 g (0.15 mol) of fluorescein (C20H12O5) was added,1.46 g (0.02 mol) of dimethylformamide (DMF)with200 ml of sulfolane (C4H8O2S),Was added to a 500 ml reactor,Stirring and heating to 60 ° C,70.8 g (0.60 mol) of thionyl chloride (SOCl2) was added dropwise,About 30 minutes dripping finished,Continue to heat up to 80 ° C,Insulation reaction 2h,The reaction ends,Cooling it to about 30 ° C,And then poured into 250ml volume ratio of 1: 1 in the mixture of acetone and water,Stirring and stirring 2h after filtration,Filter cake with 50ml volume ratio of 1:1 mixture of acetone and water leaching,Dried to light yellow intermediate A 50g,The yield was 90.5 wt% and the content was about 96.5 wt%.
References:
CN106967304,2017,A Location in patent:Paragraph 0028; 0029; 0030; 0031; 0032; 0048
2513-33-9
70 suppliers
$139.00/250mg
630-88-6
90 suppliers
$51.00/1g