fluoroacetic anhydride synthesis

Yield:-

Reaction Conditions:

with dicyclohexyl-carbodiimide in tetrahydrofuran at 25; for 2 h;

Steps:

16.2 Step 16.2: 2-fluoroacetic acid anhydride
N,N’-Dicyclohexylcarbodiimide (14.5 g, 70.5 mmol) was added to a solution of 2-fluoroaceticacid (5 g, 64 mmcl) in THF (64 mL). The reaction mixture was stirred for 2 h at 25 °C. Theprecipitate was filtered off and the filtrate was used directly for Step 16.3.

References:

NOVARTIS AG;BLANK, Jutta;BOLD, Guido;COTESTA, Simona;GUAGNANO, Vito;RUEEGER, Heinrich WO2014/191906, 2014, A1 Location in patent:Page/Page column 49

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