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104090-92-8

FMOC-GLU(OBUT)-NH2 synthesis

1synthesis methods
71989-18-9 Synthesis
Fmoc-L-glutamic acid 5-tert-butyl ester

71989-18-9
425 suppliers
$7.00/5g

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Yield:104090-92-8 99%

Reaction Conditions:

Stage #1: Fmoc-Glu(OtBu)-OHwith (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 0.333333 h;
Stage #2: with ammonia in dichloromethane;water; for 1.5 h;Further stages.;

References:

Singh, Yogendra;Stoermer, Martin J.;Lucke, Andrew J.;Glenn, Matthew P.;Fairlie, David P. [Organic Letters,2002,vol. 4,# 20,p. 3367 - 3370]