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FMoc-α-Me-Lys(Boc)-OH synthesis
- Product Name:FMoc-α-Me-Lys(Boc)-OH
- CAS Number:1202003-49-3
- Molecular formula:C27H34N2O6
- Molecular Weight:482.57
![H-α-Me-Lys(Boc)-OH](/CAS/20200515/GIF/1202003-44-8.gif)
1202003-44-8
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![N-(9-Fluorenylmethoxycarbonyloxy)succinimide](/CAS/GIF/82911-69-1.gif)
82911-69-1
607 suppliers
$7.00/25g
![FMoc-α-Me-Lys(Boc)-OH](/CAS/20180713/GIF/1202003-49-3.gif)
1202003-49-3
99 suppliers
$60.00/10mg
Yield:1202003-49-3 58.6 g
Reaction Conditions:
with anhydrous sodium carbonate in water monomer;ethyl acetate at 35; for 1 h;Reagent/catalyst;Temperature;
Steps:
1.4; 2.4; 3.4 (4) Synthesis of compound 1
The aqueous solution containing 39.3 g of compound 6 obtained in step (3) was added to the reaction flask, 450 g of ethyl acetate and 45 g of sodium carbonate were added, the temperature was adjusted to 35°C, and 45 g of N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) was added, the temperature was controlled at 35 °C, stirred for 1 h, and the remaining 1.5% of compound 6 was detected by liquid chromatography. Remove the aqueous phase. The organic phase was extracted with 900 g of purified water, the sodium salt of compound 1 was dissolved in the aqueous phase, the aqueous phase was washed twice with 390 g of methyl tert-butyl ether, the temperature was controlled at 5°C, and the pH was adjusted to 3~ 4. Stir at 5°C for 6 hours and filter. The wet product was vacuum dried at 45°C for 24 hours. After baking, 58.6 g of product was obtained with a molar yield of 80.5%, a purity of 99% (Fig. 1), a chiral purity of 100% (Fig. 2), and a total molar yield of 52.6%.
References:
CN114276278,2022,A Location in patent:Paragraph 0011; 0043; 0052-0055; 0056; 0065-0066; 0067; ...
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
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$13.50/25G
![L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-, hydrochloride (1:1)](/CAS/20210111/GIF/1453178-51-2.gif)
1453178-51-2
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![FMoc-α-Me-Lys(Boc)-OH](/CAS/20180713/GIF/1202003-49-3.gif)
1202003-49-3
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![Propanedioic acid, 2-[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl]-2-methyl-, 1,3-diethyl ester](/CAS/20200515/GIF/17377-68-3.gif)
17377-68-3
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![FMoc-α-Me-Lys(Boc)-OH](/CAS/20180713/GIF/1202003-49-3.gif)
1202003-49-3
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$60.00/10mg
![Propanedioic acid, 2-[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl]-2-methyl-, 1-ethyl ester, (2R)-](/CAS/20210305/GIF/1453179-18-4.gif)
1453179-18-4
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![FMoc-α-Me-Lys(Boc)-OH](/CAS/20180713/GIF/1202003-49-3.gif)
1202003-49-3
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$60.00/10mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![(2S)-6-amino-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylhexanoic acid](/CAS/20200119/GIF/1202003-48-2.gif)
1202003-48-2
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![FMoc-α-Me-Lys(Boc)-OH](/CAS/20180713/GIF/1202003-49-3.gif)
1202003-49-3
99 suppliers
$60.00/10mg