ChemicalBook CAS DataBase List Fmoc-N-Me-Tyr(tBu)-OH

Fmoc-N-Me-Tyr(tBu)-OH synthesis

1synthesis methods

Product Name:Fmoc-N-Me-Tyr(tBu)-OH
CAS Number:133373-24-7
Molecular formula:C29H31NO5
Molecular Weight:473.56

(9H-Fluoren-9-yl)methyl carbonochloridate could be used as the starting material to synthesize Fmoc-N-Me-Tyr(tBu)-OH.

L-Tyrosine, O-(1,1-dimethylethyl)-N-methyl-N-[(4-nitrophenyl)sulfonyl]-, 2-oxo-2-phenylethyl ester

1208119-58-7
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28920-43-6
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133373-24-7
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$17.00/250mg

Yield:133373-24-7 78%

Reaction Conditions:

Stage #1: N-methyl-N-nosyl-O-tert-butyl-L-tyrosine phenacyl esterwith sodium thiophenolate in N,N-dimethyl-formamide at 20; for 3 h;Inert atmosphere;
Stage #2: with sodium carbonate in water; pH=9;
Stage #3: (fluorenylmethoxy)carbonyl chloride in 1,4-dioxane at 0;

References:

Leggio, Antonella;Belsito, Emilia Lucia;De Marco, Rosaria;Liguori, Angelo;Perri, Francesca;Viscomi, Maria Caterina [Journal of Organic Chemistry,2010,vol. 75,# 5,p. 1386 - 1392] Location in patent:supporting information; experimental part

Fmoc-N-Me-Tyr(tBu)-OH Related Search:

Fmoc-Tyr(tBu)-OH Fmoc-N-methyl-L-phenylalanine