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FOR-ASP-PHE-OME synthesis
- Product Name:FOR-ASP-PHE-OME
- CAS Number:33605-76-4
- Molecular formula:C15H18N2O6
- Molecular Weight:322.31
Yield:33605-76-4 65.5%
Reaction Conditions:
with sodium acetate;acetic acid in ethyl acetate;
Steps:
6 Example 6
Example 6 In 100 g of ethyl acetate, 14.3 g (0.1 mole) of N-formyl-L-aspartic anhydride and 21.6 g (0.1 mole) of L-phenylalanine methyl ester hydrochloride were suspended and 9.2 g (0.11 mole) of sodium acetate was added to the suspension during 30 minutes at 20°-25° C. with stirring. The mixture was reacted for 5 hours with stirring at the same temperature. Thereafter 14.3 g of acetic acid was added and stirred for an hour at the same temperature. Precipitated crystals were filtered, washed and dried. Crystals of N-formyl-α-L-aspartyl-L-phenylalanine methyl ester were obtained in a yield of 21.1 g (65.5% yield on L-Phenylalanine methyl ester hydrochloride). The crystals obtained were analyzed by high performance liquid chromatography to give a ratio of α-isomer:β-isomer of 98.0:2.0.
References:
US5302743,1994,A