ChemicalBook CAS DataBase List Fozivudine

Fozivudine synthesis

1synthesis methods

Product Name:Fozivudine
CAS Number:141790-23-0
Molecular formula:C35H64N5O8PS
Molecular Weight:745.958

1-Propanol, 2-(decyloxy)-3-(dodecylthio)-, (2R)-

1064563-36-5
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1-Propanol, 2-(decyloxy)-3-(dodecylthio)-

134542-59-9
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141790-23-0
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Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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Yield:-

Steps:

14.2 (2)
Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (R)-2-decyloxy-3-dodecylsulfanyl-propyl ester and Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (R,S)-2-decyloxy-3-dodecylsulfanyl-propyl ester were prepared by similar procedures using (R)-1-dodecylthio-2-decyloxy-propan-3-ol and (R,S)-1-dodecylthio-2-decyloxy-propan-3-ol respectively in place of (R)-1-dodecylthio-2-decyloxy-propan-3-ol.

References:

ARDEA BIOSCIENCES, INC. US2008/249066, 2008, A1

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