ChemicalBook CAS DataBase List FURAN-2-YLMETHYL-UREA

FURAN-2-YLMETHYL-UREA synthesis

7synthesis methods

Product Name:FURAN-2-YLMETHYL-UREA
CAS Number:5962-13-0
Molecular formula:C6H8N2O2
Molecular Weight:140.14

617-89-0 Synthesis

617-89-0
264 suppliers
$16.00/25g

5962-13-0
21 suppliers
inquiry

Yield:5962-13-0 97%

Reaction Conditions:

with hydrogenchloride in water;

Steps:

3.A A.

A. Synthesis of furfurylurea Furfurylamine (5.0 g, 51.5 mmol) was slowly added to a stirring 1 M solution of anhydrous hydrogen chloride in ether (61.8 ml, 61.8 mmol) cooled to 0° C. The resulting slurry was swirled for 5 minutes then evaporated under reduced pressure to give furfurylamine hydrochloride as a pale yellow solid. This salt was dissolved in water (30 ml) then heated to 85° C. Potassium cyanate (4.2 g, 51.5 mmol) was added and the reaction stirred at 85° C. for 3 hours. After cooling to ambient temperature the solution was diluted with ethanol (100 ml). After 2 hours the resulting solid salts were removed by filtration and the filtrate was evaporated under reduced pressure to give a crude solid. Recrystallization from ethyl acetate/toluene gave a furfurylurea (7.0 g, 97% yield) as a tan solid.

References:

US6075029,2000,A

590-28-3 Synthesis