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ChemicalBook CAS DataBase List Galangin

Galangin synthesis

6synthesis methods
Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.
Synthetic Routes
  • ROUTE 1
  • 202112078511222407.jpg

    Lee, Jae In; Park, Se Bin. An effective synthesis of 3-methoxyflavones via 1-(2-hydroxyphenyl)-2-methoxy-3-phenyl-1,3-propanediones. Bulletin of the Korean Chemical Society. Volume 33. Issue 4. Pages 1379-1382. Journal. (2012).

  • ROUTE 2
  • 202112075786324123.jpg

    Chawla, H. Mohindra; Chakrabarty, Kakoli. Dye-sensitized photo-oxygenation of chalcones. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Issue 7. Pages 1511-13. Journal. (1984).

  • ROUTE 3
  • 202112074523004966.jpg

    Das, Sreeparna; Mitra, Indrani; Batuta, Shaikh; Niharul Alam, Md.; Roy, Kunal; Begum, Naznin Ara. Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues. Bioorganic & Medicinal Chemistry Letters. Volume 24. Issue 21. Pages 5050-5054. Journal; Online Computer File. (2014).

  • ROUTE 4
  • 202112072496495464.jpg

    Chen, Lili; Li, Jian; Luo, Cheng; Liu, Hong; Xu, Weijun; Chen, Gang; Liew, Oi Wah; Zhu, Weiliang; Puah, Chum Mok; Shen, Xu; Jiang, Hualiang. Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure-activity relationship studies reveal salient pharmacophore features. Bioorganic & Medicinal Chemistry. Volume 14. Issue 24. Pages 8295-8306. Journal. (2006).

  • ROUTE 5
  • 202112078695992598.jpg

    Kim, Jinyoung; Lee, Hyo Seon; Park, Kwang-su; Chong, Youhoon. . Unexpected desilylative-alkylation of 3-O-(tert-butyl-dimethylsilyl)galangin. Bulletin of the Korean Chemical Society. Volume 29. Issue 9. Pages 1667-1668. Journal. (2008).

202112078511222407.jpg

Lee, Jae In; Park, Se Bin. An effective synthesis of 3-methoxyflavones via 1-(2-hydroxyphenyl)-2-methoxy-3-phenyl-1,3-propanediones. Bulletin of the Korean Chemical Society. Volume 33. Issue 4. Pages 1379-1382. Journal. (2012).

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: aq. KOH / ethanol / 48 h / Ambient temperature
2: 54 percent Turnov. / air, methylene blue / methanol / 81 h / Irradiation

References:

Chawla, H. Mohindra;Chakrabarty, Kakoli [Journal of the Chemical Society. Perkin transactions I,1984,# 7,p. 1511 - 1513]

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