ChemicalBook CAS DataBase List GERANYL CAPROATE

GERANYL CAPROATE synthesis

5synthesis methods

Product Name:GERANYL CAPROATE
CAS Number:10032-02-7
Molecular formula:C16H28O2
Molecular Weight:252.39

By an exchange reaction between methyl caproate and geraniol in the presence of a catalyst or sodium methylate.

106-24-1
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142-62-1 Synthesis

142-62-1
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10032-02-7
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Yield: 76.72%

Reaction Conditions:

with sodium hydroxide at 80; for 8 h;

Steps:

Synthesis of geraniol ester compound
General procedure: 10 mmol of geraniol, 12 mmol of butyric acid (or caproic acid or caprylic acid), and 5% (w/w) of NaOH were arranged in a 250 mL round-bottomed flask. The mixture was stirred and heated at 80°C for 8 hours. This was followed by the neutralization of the reaction by 1% of HCl solution for the purpose of separating it from the NaOH catalyst. EtOAc was used to extract the reaction mixture and the organic phase was washed through the use of distilled water, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure at 45°C under vacuum to produce the crude ester product. The analysis of the products was conducted by TLC through the use of eluent of n-hexane: EtOAc = 95:5 and further purification was conducted through the use of column chromatography eluted with n-hexane, a gradient of EtOAc to 100%.

References:

Widiyarti, Galuh;Megawati, Megawati;Hanafi, Muhammad [Oriental Journal of Chemistry,2019,vol. 35,# 3,p. 987 - 996]

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628-02-4 Synthesis