ChemicalBook CAS DataBase List Ginkgolic acid

Ginkgolic acid synthesis

8synthesis methods

Product Name:Ginkgolic acid
CAS Number:22910-60-7
Molecular formula:C22H34O3
Molecular Weight:346.5

629-30-1 Synthesis

629-30-1
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22910-60-7
158 suppliers
$49.00/1mg

Yield:-

Steps:

Multi-step reaction with 9 steps
1: p-toluenesulfonic acid / CH₂Cl₂ / 1.5 h
2: 1.) DMSO; 2.) oxalyl chloride, triethylamine / 1.) CH₂Cl₂, -50 deg C, 5 min; 2.) CH₂Cl₂, -50 deg C 20 min, rt
3: potassium t-butoxide / 1.) THF-HMPA, -60 deg C, 30 min; 2.) -20 deg C 5 min, rt overnight
4: 95 percent / p-toluenesulfonic acid / methanol / 2 h / Ambient temperature
5: hydrogen / Pt-C / ethyl acetate
6: 1.) DMSO; 2.) oxalyl chloride, triethylamine / 1.) CH₂Cl₂, -78 deg C, 5 min; 2.) CH₂Cl, -78 deg C 5 min, rt
7: 1.) n-butyllithium / 1.) THF-hexane, 0 deg C 30 min; 2.) THF-hexane, -30 deg C 40 min, rt
8: 97 percent / NaOH / dimethylsulfoxide / 24 h / Heating
9: 67 percent / NaH, ethanethiol / dimethylformamide / 1.) 0 deg C, 30 min rt; 2.) reflux 3 h

References:

Yamagiwa, Yoshiro;Ohashi, Kinji;Sakamoto, Yoshitaka;Hirakawa, Shinji;Kamikawa, Tadao;Kubo, Isao [Tetrahedron,1987,vol. 43,# 15,p. 3387 - 3394]

5-HYDROXY-2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-4-ONE

154714-19-9
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22910-60-7
158 suppliers
$49.00/1mg

References

303-07-1 Synthesis

303-07-1
422 suppliers
$10.00/5g

22910-60-7
158 suppliers
$49.00/1mg

References

Methanesulfonic acid, 1,1,1-trifluoro-, 2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-5-yl ester

164014-40-8
11 suppliers
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22910-60-7
158 suppliers
$49.00/1mg

References

Heptanal,7-[(tetrahydro-2H-pyran-2-yl)oxy]-

34335-17-6
0 suppliers
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22910-60-7
158 suppliers
$49.00/1mg

References

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