Glycine, N-(2,2-dimethoxyethyl)-, ethyl ester synthesis
- Product Name:Glycine, N-(2,2-dimethoxyethyl)-, ethyl ester
- CAS Number:126026-17-3
- Molecular formula:C8H17NO4
- Molecular Weight:191.22
Yield: 71%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20;
Steps:
6.1 Step 1: ethyl 2-(2,2-dimethoxyethylamino)acetate
A mixture of 2,2-dimethoxyethanamine (5.0 g, 47.55 mmol), ethyl 2-bromoacetate (7.9 g, 47.30 mmol) and K2CO3 (6.64 g, 48.04 mmol) in DMF (40 mL) was stirred at room temperature overnight. Solvent was removed in vacuo, and the residue was purified by silica gel column (DCM:MeOH 20:1) to give the desired product ethyl 2-(2,2-dimethoxyethylamino)acetate as a colorless oil (6.5 g). Yield 71% (ESI 191.0 (M+H)+).
References:
Lazuli, Inc.;Harrison, Bryce A.;Bursavich, Matthew G.;Brewer, Mark;Gerasyuto, Aleksey I.;Hahn, Kristopher N.;Konze, Kyle D.;Lin, Fu-Yang;Lippa, Blaise S.;Lugovskoy, Alexey A.;Rogers, Bruce N.;Svensson, Mats A.;Troast, Dawn M. US2018/244648, 2018, A1 Location in patent:Paragraph 0227; 0228
22483-09-6
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