Glycine,N-(3-fluorophenyl)-, ethyl ester synthesis
- Product Name:Glycine,N-(3-fluorophenyl)-, ethyl ester
- CAS Number:2573-30-0
- Molecular formula:C10H12FNO2
- Molecular Weight:197.21
Yield:2573-30-0 40%
Reaction Conditions:
with iron(II) triflate;[Ir(ppy)2(MeCN)2]PF6 in methanol; for 24 h;Inert atmosphere;Irradiation;Cooling;Sealed tube;
Steps:
3 Example 3
At room temperature, add 11.1 mg (0.1 mmol) 3-fluoroaniline, 22.8 mg (0.2 mmol) ethyl diazoacetate, 7.1 mg (0.02 mmol) ferrous trifluoromethanesulfonate, 3.7 mg to a 10 mL round bottom flask at room temperature (5.0mol%) [Ir(ppy)2(MeCN)2] PF6 and 1mL of anhydrous methanol, sealed with a rubber stopper and parafilm, then freeze and deoxygenate under the protection of nitrogen, and place it under 30W blue LEDs. Light for 24 hours with constant stirring. The progress of the reaction was monitored by TLC.Post-treatment: After the reaction is completed, the reaction solvent is concentrated and spin-dried on a rotary evaporator, and then a mixture solution of petroleum ether: ethyl acetate with a volume ratio of 20:1 is used as a developing solvent for thin-layer chromatography silica gel plate purification and separation. The corresponding N-arylglycine ester derivatives are obtained, and the reaction formula is:The purity of the product is 99%, and the yield is 40%.
References:
CN111333526,2020,A Location in patent:Paragraph 0041-0046
