Glycine,N-(4-bromobenzoyl)- synthesis

6synthesis methods

Product Name:Glycine,N-(4-bromobenzoyl)-
CAS Number:18815-75-3
Molecular formula:C9H8BrNO3
Molecular Weight:258.07

56-40-6 Synthesis

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Yield:18815-75-3 96.89%

Reaction Conditions:

with alkaline hydroxide at 0; for 0.5 h;

Steps:

1 2.1.1 Preparation of 4-Bromohippuric acid (1)

According to previously published procedure [32], a solution of glycine (8.25gm, 0.11Mol) and potassium hydroxide (0.2Mol, in 50mL) was cooled to 0°C then 4-Bromobenzoylchlororide (21.95gm, 0.1Mol) was added in two portions with shaking. Further, the reaction mixture was stirred for 30 min. After that, the solution was acidified with conc. HCl and the product was collected (25gm) and recrystallized from ethanol. Yield: 96.89%, M.P: found (155-157) °C, IR. (KBr) (ν_max, Cm^-1) 3296 (NH), 2550-3296 (acid OH), 1703 (acid C=O), 1635 (amide C=O).

References:

Samad, Mohammed Kareem;Hawaiz, Farouq Emam [Bioorganic Chemistry,2019,vol. 85,p. 431 - 444]