ChemicalBook CAS DataBase List H-9 2HCL

H-9 2HCL synthesis

6synthesis methods

Product Name:H-9 2HCL
CAS Number:84468-17-7
Molecular formula:C11H13N3O2S
Molecular Weight:251.3

107-15-3
9 suppliers
$11.19/25ML

105627-79-0 Synthesis

Isoquinoline-5-sulphonyl chloride hydrochloride

105627-79-0
145 suppliers
$20.00/100mg

84468-17-7
43 suppliers
$110.09/10mg

Yield:84468-17-7 89%

Reaction Conditions:

in chloroform at 20; for 1 h;

Steps:

2 Preparation 2; Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide

Powdered isoquinoline-5-sulfonyl chloride hydrochloride (5.57 g, 21.1 mmol) is added in small portions to a stirred solution of ethylenediamine (45.0 mL, 673 MMOL) in CHC13 (400 ML) at ambient temperature under nitrogen. The resultant mixture is stirred for 1 hour. After filtration and concentration in vacuo, the crude product is chromatographed on silica (gradient 5-10% CH30H in CH2C12, then 0-16% 2M NH3/CH30H in CH2C12) to give 4.71 g (18.7 mmol, 89% yield) of the title compound. ESIMS: m/z 252 (M+H) +.

References:

WO2004/94386,2004,A1 Location in patent:Page 17

27655-40-9 Synthesis