H-D-ABU-OTBU HCL synthesis

Yield:313994-32-0 46%

Reaction Conditions:

with perchloric acid at 20; for 48 h;

Steps:

tert-Butyl 2-aminobutanoates

General procedure: A solution of the commerciallyavailable enantiopure 2-aminobutyric acid (1.00 g, 10 mmol) and perchloric acid(70%, 5.0 g, 83 mmol) in tert-butylacetate(150 mL) was stirred at r.t. for 48 h and extracted with cold (0 °C) 0.5 Mhydrochloric acid (2 × 50 mL). Thecombined aqueous layers were carefully neutralized with solid NaHCO₃and extracted with diethyl ether (3 × 100 mL). The combined organic layers were dried overMgSO₄ and the solvent was evaporated to give the product (>98 %,GC) as a viscose oil, which was used without further purification.

References:

Behrends, Malte;Wagner, Stefan;Kopka, Klaus;Schober, Otmar;Sch?fers, Michael;Kumbhar, Sadhana;Waller, Mark;Haufe, Günter [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 13,art. no. 12204,p. 3809 - 3818] Location in patent:supporting information