![](/CAS/GIF/313994-32-0.gif)
H-D-ABU-OTBU HCL synthesis
- Product Name:H-D-ABU-OTBU HCL
- CAS Number:313994-32-0
- Molecular formula:C8H17NO2
- Molecular Weight:159.23
![tert-Butyl acetate](/CAS/GIF/540-88-5.gif)
540-88-5
352 suppliers
$24.00/25mL
![D-2-Aminobutyric acid](/CAS/GIF/2623-91-8.gif)
2623-91-8
370 suppliers
$5.00/5g
![H-D-ABU-OTBU HCL](/CAS/GIF/313994-32-0.gif)
313994-32-0
42 suppliers
$33.60/1G
Yield:313994-32-0 46%
Reaction Conditions:
with perchloric acid at 20; for 48 h;
Steps:
tert-Butyl 2-aminobutanoates
General procedure: A solution of the commerciallyavailable enantiopure 2-aminobutyric acid (1.00 g, 10 mmol) and perchloric acid(70%, 5.0 g, 83 mmol) in tert-butylacetate(150 mL) was stirred at r.t. for 48 h and extracted with cold (0 °C) 0.5 Mhydrochloric acid (2 × 50 mL). Thecombined aqueous layers were carefully neutralized with solid NaHCO3and extracted with diethyl ether (3 × 100 mL). The combined organic layers were dried overMgSO4 and the solvent was evaporated to give the product (>98 %,GC) as a viscose oil, which was used without further purification.
References:
Behrends, Malte;Wagner, Stefan;Kopka, Klaus;Schober, Otmar;Sch?fers, Michael;Kumbhar, Sadhana;Waller, Mark;Haufe, Günter [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 13,art. no. 12204,p. 3809 - 3818] Location in patent:supporting information