H-LYS(2-CHLORO-Z)-OBZL HCL synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 20; for 2 h;

Steps:

5 The Preparation of Hcl.Lys(ClZ)-OBzl

EXAMPLE 5 The Preparation of Hcl.Lys(ClZ)-OBzl The solution of 100 mg (0.2 mmol) of Boc-Lys(ClZ)-OBzl in 3 ml of hydrogen chloride in ethyl acetate (4 mol/L) was stirred at room temperature for 2 h and TLC (chloroform/methanol, 40:1) indicated complete disappearance of Boc-Lys(ClZ)-OBzl. The reaction mixture was evaporated under reduced pressure with ethyl acetate, repeatedly, to remove hydrogen chloride. The residue was triturated with ether to provide the title compound as a colorless powder, which was used for the next reaction directly.

References:

US2005/80015,2005,A1 Location in patent:Page/Page column 5