ChemicalBook CAS DataBase List H-PRO-GLY-GLY-OH

H-PRO-GLY-GLY-OH synthesis

6synthesis methods

Product Name:H-PRO-GLY-GLY-OH
CAS Number:7561-25-3
Molecular formula:C9H15N3O4
Molecular Weight:229.23

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7561-25-3
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Yield:7561-25-3 85%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; under 760.051 Torr; for 2 h;

Steps:

Deprotection of Cbz of Cbz-protected tipeptide

General procedure: To a solution of Cbz-protected tripeptide (2 mmol) in MeOH (30 mL), 10% Pd/C was added at room temperature. After stirred under hydrogen (1 atm) for 2 h at room temperature, The resulting mixture was filtered. After the removal of solvent under reduced pressure, corresponding tripeptide was obtained.

References:

Kon, Kazumasa;Kohari, Yoshihito;Murata, Miki [Tetrahedron Letters,2019,vol. 60,# 5,p. 415 - 418] Location in patent:supporting information

3304-59-4 Synthesis