![](/CAS/GIF/871836-51-0.gif)
HDH-PHARMA 26173 synthesis
- Product Name:HDH-PHARMA 26173
- CAS Number:871836-51-0
- Molecular formula:C6H4ClN3
- Molecular Weight:153.57
![2,4-Dichloropyridine-3-carboxaldehyde](/CAS/GIF/134031-24-6.gif)
134031-24-6
194 suppliers
$30.00/1g
![HDH-PHARMA 26173](/CAS/GIF/871836-51-0.gif)
871836-51-0
165 suppliers
$30.00/1g
Yield:871836-51-0 56%
Reaction Conditions:
with hydrazine hydrate in 1,2-dimethoxyethane at 20 - 75;
Steps:
Intermediate 24-Chlora-1 H-pyrazolo[4, 3-c]pyridineTo a solution of Intermediate 1 (1.7 g, 9.7 mmol) in dimethoxyethane (12 ml) at room temperature was added hydrazine monohydrate (1.2 ml, 38.6 mmol) and the resulting mixture was stirred at 75 °C overnight. The mixture was then concentrated to dryness and the crude residue was purified by flash chromatography, eluting with 20 to 100% ethyl acetate/petroleum ether gradient to give a white solid (0.82 g, 56%). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.60 (d, J=6.9 Hz, 1 H), 8.14 (d, J=6.0 Hz, 1 H), 8.32 (s, 1 H); m/z (ES+APCI)+: 154 [M + H]+.
References:
MEDICAL RESEARCH COUNCIL TECHNOLOGY;GENENTECH INC.;CHAN, Bryan;CHEN, Huifen;ESTRADA, Anthony;SHORE, Daniel;SWEENEY, Zachary;McIVER, Edward WO2012/38743, 2012, A1 Location in patent:Page/Page column 82
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153034-90-3
188 suppliers
$10.00/250mg
![HDH-PHARMA 26173](/CAS/GIF/871836-51-0.gif)
871836-51-0
165 suppliers
$30.00/1g
![1H-pyrazolo[3,4-c]pyridine 6-oxide](/CAS/20210111/GIF/871836-50-9.gif)
871836-50-9
2 suppliers
inquiry
![HDH-PHARMA 26173](/CAS/GIF/871836-51-0.gif)
871836-51-0
165 suppliers
$30.00/1g
![1H-pyrazolo[3,4-c]pyridine 6-oxide](/CAS/20210111/GIF/871836-50-9.gif)
871836-50-9
2 suppliers
inquiry
![HDH-PHARMA 26173](/CAS/GIF/871836-51-0.gif)
871836-51-0
165 suppliers
$30.00/1g
![6-Chloro-1H-pyrazolo[4,3-c]pyridine](/CAS/GIF/1206979-33-0.gif)
1206979-33-0
163 suppliers
$17.00/250mg
![2,4-Dichloropyridine](/CAS/GIF/26452-80-2.gif)
26452-80-2
402 suppliers
$7.00/5g
![HDH-PHARMA 26173](/CAS/GIF/871836-51-0.gif)
871836-51-0
165 suppliers
$30.00/1g