ChemicalBook CAS DataBase List HEROIN

HEROIN synthesis

6synthesis methods

Product Name:HEROIN
CAS Number:561-27-3
Molecular formula:C21H23NO5
Molecular Weight:369.42

57-27-2
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$18.00/1mg

561-27-3
2 suppliers
$19.00/1mg

Yield:-

Reaction Conditions:

with pyridine;acetic anhydride in dichloromethane

Steps:

2.8.A 3-[(N-normorphino)acetamindo]-2,2,5,5-tetramethylpyrrolidinyl-1-oxyl
A. Morphine (8.66 g) was acetylated with acetic anhydride (32 g) and pyridine (25 g) at room temperature overnight. After removal of the solvents by azeotroping with benzene, the residue was dissolved in dichloromethane, washed with saturated sodium chloride solution, 2.5% sodium chloride solution, 2.5% sodium carbonate solution, 2N-hydrochloric acid, and finally, saturated sodium chloride solution. Evaporation of the dichloromethane after drying over anhydrous sodium sulfate afforded heroin in a solid state (10.59 g) mp 169°-173°.

References:

Syva Company US3959287, 1976, A Syva Company US3966744, 1976, A

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