![](/CAS/20180529/GIF/65920-18-5.gif)
Hydroxylamine, O-(2-bromoethyl)-, hydrobromide synthesis
- Product Name:Hydroxylamine, O-(2-bromoethyl)-, hydrobromide
- CAS Number:65920-18-5
- Molecular formula:C2H7Br2NO
- Molecular Weight:220.8911
![N-(2-Bromoethoxy)phthalimide](/CAS2/GIF/5181-35-1.gif)
5181-35-1
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![Hydroxylamine, O-(2-bromoethyl)-, hydrobromide](/CAS/20180529/GIF/65920-18-5.gif)
65920-18-5
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Yield:65920-18-5 74%
Reaction Conditions:
with hydrogen bromide;acetic acid in water monomer at 120; for 0.25 h;
Steps:
7 Intermediate R: 0-(2-Bromoethyl)hydroxylamine, HBr
2-(2-Bromoethoxy)isoindoline-1 ,3-dione (Intermediate Q) (1.00 g, 3.70 mmol) was combined with cone HBr (48 wt% in water, 4.5 mL) and acetic acid (3 mL, 52.4 mmol). The mixture was heated at 120 °C for 15 min. The reaction mixture was cooled, the precipitate was removed by filtration and the filtrate concentrated under reduced pressure to afford the subtitle compound 0-(2-Bromoethyl)hydroxylamine, HBr as a tan solid (550 mg, 74%); 1 H NMR δ: 3.72 (2H, m), 4.28 (2H, m), 10.70 (3H, br s).
References:
WO2017/109513,2017,A1 Location in patent:Page/Page column 40