Hydroxylamine, O-(2-bromoethyl)-, hydrobromide synthesis

Yield:65920-18-5 74%

Reaction Conditions:

with hydrogen bromide;acetic acid in water monomer at 120; for 0.25 h;

Steps:

7 Intermediate R: 0-(2-Bromoethyl)hydroxylamine, HBr

2-(2-Bromoethoxy)isoindoline-1 ,3-dione (Intermediate Q) (1.00 g, 3.70 mmol) was combined with cone HBr (48 wt% in water, 4.5 mL) and acetic acid (3 mL, 52.4 mmol). The mixture was heated at 120 °C for 15 min. The reaction mixture was cooled, the precipitate was removed by filtration and the filtrate concentrated under reduced pressure to afford the subtitle compound 0-(2-Bromoethyl)hydroxylamine, HBr as a tan solid (550 mg, 74%); ¹ H NMR δ: 3.72 (2H, m), 4.28 (2H, m), 10.70 (3H, br s).

References:

WO2017/109513,2017,A1 Location in patent:Page/Page column 40