Hydroxypioglitazone synthesis
- Product Name:Hydroxypioglitazone
- CAS Number:146062-44-4
- Molecular formula:C19H20N2O4S
- Molecular Weight:372.44
5470-70-2
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146062-44-4
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Yield:-
Steps:
Multi-step reaction with 9 steps
1: NaH / dimethylformamide; toluene / 2.5 h / 80 °C
2: 10percent aq. H2SO4 / 2 h / Heating
3: 90 percent / NaBH4 / ethanol / 1.5 h / 0 °C
4: 1.) NaH / 1.) hexane, DMF, 0 deg C, 1.5 h, 2.) hexane, DMF, from -78 deg C to RT
5: 27 percent / H2O / 5 h / 160 °C
6: 62 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature
7: 58 percent / piperidine / ethanol / 18 h / Heating
8: 61 percent / NaBH4, 1.0N aq. NaOH, CoCl2*6H2O, 2,2'-dipyridyl / dimethylformamide / 42 h / Ambient temperature
9: 98 percent / 2N aq. HCl / methanol / 2 h / Heating
References:
Tanis, Steven P.;Parker, Timothy T.;Colca, Jerry R.;Fisher, Roberta M.;Kletzein, Rolf F. [Journal of Medicinal Chemistry,1996,vol. 39,# 26,p. 5053 - 5063]
184766-39-0
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146062-44-4
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1000210-73-0
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146062-44-4
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36357-38-7
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$15.00/250mg
146062-44-4
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146062-57-9
7 suppliers
$1320.00/500mg
146062-44-4
72 suppliers
$225.00/1mg