ChemicalBook CAS DataBase List Ibrutinib D5

Ibrutinib D5 synthesis

2synthesis methods

Product Name:Ibrutinib D5
CAS Number:1553977-17-5
Molecular formula:C25H24N6O2
Molecular Weight:440.51

1276110-38-3 Synthesis

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
49 suppliers
$18.00/100mg

1553977-17-5
44 suppliers
$104.00/500μg

Yield:-

Steps:

Multi-step reaction with 6 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 80 °C
2: triethylamine / dichloromethane / 10 h / 20 °C
3: ammonium formate; palladium on activated charcoal / ethanol / 2 h / 80 °C / Inert atmosphere
4: copper(II) sulfate / dichloromethane / 20 h / 20 - 30 °C
5: hydrogenchloride / water; ethanol / 3 h / 60 °C
6: triethylamine / tetrahydrofuran / 2 h / 0 - 10 °C

References:

Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.;Song Huafeng;Hu Yongzhu;Liu Chun;Fan Gaojun CN109988175, 2019, A

146631-00-7
256 suppliers
$6.00/1g

1553977-17-5
44 suppliers
$104.00/500μg

References

Ibrutinib D5 Related Search:

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine Btk inhibitor 1 (R enantioMer hydrochloride)